5DJY

Fc Heterodimer Design 20.8 Y349S/T366V/K370Y/K409V + E357D/S364Q/Y407A

5DJY の概要

• エントリーDOI: 10.2210/pdb5djy/pdb
• 関連するPDBエントリー: 5DI8 5DJ0 5DJ2 5DJ6 5DJ8 5DJA 5DJC 5DJD 5DJX 5DJZ 5DK0 5DK2 5DVK 5DVL 5DVM 5DVN 5DVO
• 分子名称: Ig gamma-1 chain C region, Fc-III peptide, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: heterodimer, immunoglobulin, ch3, fc, bispecific antibody, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted : P01857 P01857
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 56834.47

構造登録者

Atwell, S.,Leaver-Fay, A.,Froning, K.J.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Dhanani, S.H.,Chamberlain, A.K.,Fitchett, J.R.,Gutierrez, B.,Hendle, J.,Demarest, S.J.,Kuhlman, B. (登録日: 2015-09-02, 公開日: 2016-03-30, 最終更新日: 2020-07-29)

• 主引用文献: Leaver-Fay, A.,Froning, K.J.,Atwell, S.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Hassanali, S.,Chamberlain, A.K.,Fitchett, J.R.,Demarest, S.J.,Kuhlman, B.; Computationally Designed Bispecific Antibodies using Negative State Repertoires.; Structure, 24:641-651, 2016; PubMed: 26996964; DOI: 10.1016/j.str.2016.02.013

実験手法

X-RAY DIFFRACTION (2.15 Å)