5DI8

Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V

Summary for 5DI8

Related5DJ0 5DJ2 5DJ6 5DJ8 5DJA 5DJC 5DJD 5DJX 5DJY 5DJZ 5DK0 5DK2 5DVK 5DVL 5DVM 5DVN 5DVO
DescriptorIg gamma-1 chain C region, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ... (9 entities in total)
Functional Keywordsheterodimer, immunoglobulin, ch3, fc, bispecific antibody, immune system
Biological sourceHomo sapiens (Human)
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Cellular locationSecreted  P01857 P01857
Total number of polymer chains3
Total molecular weight57190.84
Authors
Primary citation
Leaver-Fay, A.,Froning, K.J.,Atwell, S.,Aldaz, H.,Pustilnik, A.,Lu, F.,Huang, F.,Yuan, R.,Hassanali, S.,Chamberlain, A.K.,Fitchett, J.R.,Demarest, S.J.,Kuhlman, B.
Computationally Designed Bispecific Antibodies using Negative State Repertoires.
Structure, 24:641-651, 2016
PubMed: 26996964 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2016.02.013
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.280402.8%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution