5A3C
Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD
Summary for 5A3C
Entry DOI | 10.2210/pdb5a3c/pdb |
Related | 5A35 5A3A 5A3B |
Descriptor | SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ... (6 entities in total) |
Functional Keywords | transferase, adp-ribosyltransferase, metalloprotein, nad-dependent, lipoylation, regulatory enzyme, rossmann fold, zinc binding, ros defense |
Biological source | STREPTOCOCCUS PYOGENES |
Total number of polymer chains | 1 |
Total formula weight | 36234.75 |
Authors | Rack, J.G.M.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I. (deposition date: 2015-05-28, release date: 2015-07-29, Last modification date: 2024-05-08) |
Primary citation | Rack, J.G.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I. Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens. Mol.Cell, 59:309-, 2015 Cited by PubMed: 26166706DOI: 10.1016/J.MOLCEL.2015.06.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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