5A3C

Crystal structure of the ADP-ribosylating sirtuin (SirTM) from Streptococcus pyogenes in complex with NAD

Summary for 5A3C

Entry DOI	10.2210/pdb5a3c/pdb
Related	5A35 5A3A 5A3B
Descriptor	SIR2 FAMILY PROTEIN, GLYCINE, ZINC ION, ... (6 entities in total)
Functional Keywords	transferase, adp-ribosyltransferase, metalloprotein, nad-dependent, lipoylation, regulatory enzyme, rossmann fold, zinc binding, ros defense
Biological source	STREPTOCOCCUS PYOGENES
Total number of polymer chains	1
Total formula weight	36234.75
Authors	Rack, J.G.M.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I. (deposition date: 2015-05-28, release date: 2015-07-29, Last modification date: 2015-10-07)
Primary citation	Rack, J.G.,Morra, R.,Barkauskaite, E.,Kraehenbuehl, R.,Ariza, A.,Qu, Y.,Ortmayer, M.,Leidecker, O.,Cameron, D.R.,Matic, I.,Peleg, A.Y.,Leys, D.,Traven, A.,Ahel, I. Identification of a Class of Protein Adp-Ribosylating Sirtuins in Microbial Pathogens. Mol.Cell, 59:309-, 2015 Cited by PubMed: 26166706 DOI: 10.1016/J.MOLCEL.2015.06.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation