5V87
Crystal structure of LARP1-unique domain DM15 bound to m7GpppC
Summary for 5V87
Entry DOI | 10.2210/pdb5v87/pdb |
Related | 5v7c |
Descriptor | La-related protein 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate, ... (4 entities in total) |
Functional Keywords | cap-binding, rna-binding, dm15, 5'top, rna binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q6PKG0 |
Total number of polymer chains | 2 |
Total formula weight | 40535.20 |
Authors | Berman, A.J.,Lahr, R.M. (deposition date: 2017-03-21, release date: 2017-04-19, Last modification date: 2023-10-04) |
Primary citation | Lahr, R.M.,Fonseca, B.D.,Ciotti, G.E.,Al-Ashtal, H.A.,Jia, J.J.,Niklaus, M.R.,Blagden, S.P.,Alain, T.,Berman, A.J. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife, 6:-, 2017 Cited by PubMed: 28379136DOI: 10.7554/eLife.24146 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.692 Å) |
Structure validation
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