5LPM
Crystal structure of the bromodomain of human Ep300 bound to the inhibitor XDM3d
Summary for 5LPM
Entry DOI | 10.2210/pdb5lpm/pdb |
Related | 5NRW |
Descriptor | Histone acetyltransferase p300, ~{N}-[(1~{S},2~{S})-7-chloranyl-2-oxidanyl-1,2,3,4-tetrahydronaphthalen-1-yl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole -2-carboxamide, ACETATE ION, ... (4 entities in total) |
Functional Keywords | bromodomain, protein-inhibitor complex, epigenetics, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q09472 |
Total number of polymer chains | 2 |
Total formula weight | 29330.17 |
Authors | Huegle, M.,Wohlwend, D.,Gerhardt, S. (deposition date: 2016-08-13, release date: 2017-08-16, Last modification date: 2024-05-01) |
Primary citation | Hugle, M.,Lucas, X.,Ostrovskyi, D.,Regenass, P.,Gerhardt, S.,Einsle, O.,Hau, M.,Jung, M.,Breit, B.,Gunther, S.,Wohlwend, D. Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles. Angew. Chem. Int. Ed. Engl., 56:12476-12480, 2017 Cited by PubMed: 28766825DOI: 10.1002/anie.201705516 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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