5IRZ

Structure of TRPV1 determined in lipid nanodisc

Summary for 5IRZ

• Entry DOI: 10.2210/pdb5irz/pdb
• Related: 5IRX 5IS0
• EMDB information: 5778 8117 8118 8119 8120
• Descriptor: Transient receptor potential cation channel subfamily V member 1, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, ... (4 entities in total)
• Functional Keywords: trp, ion channel, nanodisc, vanilloid, lipid, transport protein
• Biological source: Rattus norvegicus (Rat); More
• Total number of polymer chains: 4
• Total formula weight: 302472.31

Authors

Gao, Y.,Cao, E.,Julius, D.,Cheng, Y. (deposition date: 2016-03-15, release date: 2016-05-25, Last modification date: 2024-03-06)

• Primary citation: Gao, Y.,Cao, E.,Julius, D.,Cheng, Y.; TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.; Nature, 534:347-351, 2016; PubMed: 27281200; DOI: 10.1038/nature17964

Experimental method

ELECTRON MICROSCOPY (3.28 Å)