5EW3
Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993
Summary for 5EW3
Entry DOI | 10.2210/pdb5ew3/pdb |
Descriptor | Vascular endothelial growth factor receptor 2, 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total) |
Functional Keywords | kdr, kinase domain, atp-binding site, vegfr2 inhibitors, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 2 |
Total formula weight | 73132.24 |
Authors | Stark, W.,Goepfert, A. (deposition date: 2015-11-20, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Bold, G.,Schnell, C.,Furet, P.,McSheehy, P.,Bruggen, J.,Mestan, J.,Manley, P.W.,Druckes, P.,Burglin, M.,Durler, U.,Loretan, J.,Reuter, R.,Wartmann, M.,Theuer, A.,Bauer-Probst, B.,Martiny-Baron, G.,Allegrini, P.,Goepfert, A.,Wood, J.,Littlewood-Evans, A. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J.Med.Chem., 59:132-146, 2016 Cited by PubMed: 26629594DOI: 10.1021/acs.jmedchem.5b01582 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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