5EGR
tRNA guanine transglycosylase (TGT) in complex with an Immucillin derivative
Summary for 5EGR
Entry DOI | 10.2210/pdb5egr/pdb |
Related | 1P0D 1PUD 4KWO 4LBU 4LEQ |
Descriptor | Queuine tRNA-ribosyltransferase, GLYCEROL, ZINC ION, ... (6 entities in total) |
Functional Keywords | transition state analog, shigellosis, immucillin, modeling, transferase, transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) |
Total number of polymer chains | 1 |
Total formula weight | 43686.82 |
Authors | Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2024-01-10) |
Primary citation | Ehrmann, F.R.,Hohn, C.,Haertsch, A.,Trapp, N.,Heine, A.,Klebe, G.,Diederich, F. Synthesis of an Immucillin Derivative as a Class of tRNA-Guanine Transglycosylase Inhibitors: Exploration of a Transition State Analogous Binding Mode To be Published, |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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