4ZYV

Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid (AGF71)

Summary for 4ZYV

Entry DOI	10.2210/pdb4zyv/pdb
Related	1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 4EW2 4EW3 4PN5 4ZYT 4ZYU 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3
Descriptor	Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-({5-[4-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid, ... (4 entities in total)
Functional Keywords	gar transformylase, antifolate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	23555.79
Authors	Deis, S.M.,Dann III, C.E. (deposition date: 2015-05-22, release date: 2016-04-20, Last modification date: 2023-09-27)
Primary citation	Deis, S.M.,Doshi, A.,Hou, Z.,Matherly, L.H.,Gangjee, A.,Dann, C.E. Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. Biochemistry, 55:4574-4582, 2016 Cited by PubMed: 27439469 DOI: 10.1021/acs.biochem.6b00412 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.053 Å)

Structure validation