4ZYC
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5
Summary for 4ZYC
Entry DOI | 10.2210/pdb4zyc/pdb |
Related | 4DIJ 4OQ3 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (S)-2-(2-((2H-tetrazol-5-yl)methoxy)-4-methylphenyl)-1-(4-chlorophenyl)-6,7-diethoxy-1,2-dihydroisoquinolin-3(4H)-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | ppi with p53, inhibitor complex, ligase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 3 |
Total formula weight | 35214.11 |
Authors | Kallen, J. (deposition date: 2015-05-21, release date: 2015-07-22, Last modification date: 2024-01-10) |
Primary citation | Gessier, F.,Kallen, J.,Jacoby, E.,Chene, P.,Stachyra-Valat, T.,Ruetz, S.,Jeay, S.,Holzer, P.,Masuya, K.,Furet, P. Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode. Bioorg.Med.Chem.Lett., 25:3621-3625, 2015 Cited by PubMed: 26141769DOI: 10.1016/j.bmcl.2015.06.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)