4ZYC
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 4SS A 201 |
| Chain | Residue |
| A | LEU54 |
| B | 4SS201 |
| B | HOH306 |
| A | PHE55 |
| A | LEU57 |
| A | GLY58 |
| A | PHE86 |
| A | VAL93 |
| A | HIS96 |
| A | ILE99 |
| B | PHE55 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 4SS A 202 |
| Chain | Residue |
| A | GLU95 |
| A | HIS96 |
| A | ARG97 |
| A | LYS98 |
| A | THR101 |
| A | HOH312 |
| A | HOH334 |
| C | LEU54 |
| C | GLY58 |
| C | ILE61 |
| C | PHE86 |
| C | HIS96 |
| C | HOH303 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 4SS B 201 |
| Chain | Residue |
| A | PHE55 |
| A | 4SS201 |
| B | LYS51 |
| B | LEU54 |
| B | PHE55 |
| B | LEU57 |
| B | GLY58 |
| B | PHE86 |
| B | VAL93 |
| B | HIS96 |
| B | ILE99 |
| B | HOH306 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 201 |
| Chain | Residue |
| C | LYS45 |
| C | ASP46 |
| C | THR47 |
