4ZYC
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11172.0 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | D, E, F (A, B) | (S)-2-(2-((2H-tetrazol-5-yl)methoxy)-4-methylphenyl)-1-(4-chlorophenyl)-6,7-diethoxy-1,2-dihydroisoquinolin-3(4H)-one | non-polymer | 534.0 | 3 | Chemie (4SS) | |||
| 3 | G (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | H, I, J (A, B, C) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
A, B, C: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33516.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1698.1 | |
| All* | Total formula weight | 35214.1 |
