4ZVQ
Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to VEID inhibitor.
Summary for 4ZVQ
Entry DOI | 10.2210/pdb4zvq/pdb |
Related | 1F1J 3EDR 4ZVO 4ZVP 4ZVR 4ZVS 4ZVT 4ZVU |
Related PRD ID | PRD_000976 |
Descriptor | Caspase-7, Peptide ACE-VAL-GLU-ILE-ASA, ... (4 entities in total) |
Functional Keywords | directed evolution, protease, peptide inhibitor, designed active site specificity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 71507.01 |
Authors | Hill, M.E.,MacPherson, D.J.,Hardy, J.A. (deposition date: 2015-05-18, release date: 2016-04-20, Last modification date: 2023-11-15) |
Primary citation | Hill, M.E.,MacPherson, D.J.,Wu, P.,Julien, O.,Wells, J.A.,Hardy, J.A. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11:1603-1612, 2016 Cited by PubMed: 27032039DOI: 10.1021/acschembio.5b00971 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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