4ZPR

Crystal Structure of the Heterodimeric HIF-1a:ARNT Complex with HRE DNA

Summary for 4ZPR

• Entry DOI: 10.2210/pdb4zpr/pdb
• Related: 4ZP4 4ZPH 4ZPK
• Descriptor: Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-alpha, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ... (4 entities in total)
• Functional Keywords: arnt, hif-1a, hre, bhlh-pas, protein transport-transcription-dna complex, protein transport/transcription/dna
• Biological source: Mus musculus (Mouse); More
• Cellular location: Nucleus: P53762; Cytoplasm : Q61221
• Total number of polymer chains: 4
• Total formula weight: 96229.26

Authors

Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F. (deposition date: 2015-05-08, release date: 2015-08-12, Last modification date: 2023-09-27)

• Primary citation: Wu, D.,Potluri, N.,Lu, J.,Kim, Y.,Rastinejad, F.; Structural integration in hypoxia-inducible factors.; Nature, 524:303-308, 2015; PubMed: 26245371; DOI: 10.1038/nature14883

Experimental method

X-RAY DIFFRACTION (3.902 Å)