4ZJV
crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein
Summary for 4ZJV
Entry DOI | 10.2210/pdb4zjv/pdb |
Related | 4R3P 4R3R |
Descriptor | Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (3 entities in total) |
Functional Keywords | epidermal growth factor receptor (egfr), erbb receptor feedback inhibitor 1, mitogen-inducible gene 6 protein(mig6), transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 Cytoplasm : Q9UJM3 |
Total number of polymer chains | 4 |
Total formula weight | 90880.29 |
Authors | |
Primary citation | Park, E.,Kim, N.,Ficarro, S.B.,Zhang, Y.,Lee, B.I.,Cho, A.,Kim, K.,Park, A.K.,Park, W.Y.,Murray, B.,Meyerson, M.,Beroukhim, R.,Marto, J.A.,Cho, J.,Eck, M.J. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22:703-711, 2015 Cited by PubMed: 26280531DOI: 10.1038/nsmb.3074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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