4ZE3

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140H mutant complexed with fluconazole

4ZE3 の概要

• エントリーDOI: 10.2210/pdb4ze3/pdb
• 関連するPDBエントリー: 4K0F 4LXJ 4WMZ 4ZDY 4ZDZ 4ZE0 4ZE1 4ZE2
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
• 機能のキーワード: fluconazole, cyp51, oxidoreductase-oxidoreductase inhibitor complex, y140h, resistance mutation, oxidoreductase-oxidoreducatse inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62782.94

構造登録者

Sagatova, A.,Keniya, M.V.,Wilson, R.,Monk, B.C.,Tyndall, J.D.A. (登録日: 2015-04-20, 公開日: 2016-03-30, 最終更新日: 2023-09-27)

• 主引用文献: Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C.; Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.; Sci Rep, 6:26213-26213, 2016; PubMed: 27188873; DOI: 10.1038/srep26213

実験手法

X-RAY DIFFRACTION (2.2 Å)