4ZCS

Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase in complex with CDP-choline

Summary for 4ZCS

Entry DOI	10.2210/pdb4zcs/pdb
Related	4ZCP 4ZCQ 4ZCR
Descriptor	Choline-phosphate cytidylyltransferase, [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... (4 entities in total)
Functional Keywords	enzyme, malaria, cytidylyltransferase, phosphatidylcholine, transferase
Biological source	Plasmodium falciparum (isolate 3D7)
Total number of polymer chains	6
Total formula weight	128443.45
Authors	Guca, E.,Hoh, F.,Guichou, J.-F.,Cerdan, R. (deposition date: 2015-04-16, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Guca, E.,Nagy, G.N.,Hajdu, F.,Marton, L.,Izrael, R.,Hoh, F.,Yang, Y.,Vial, H.,Vertessy, B.G.,Guichou, J.F.,Cerdan, R. Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis. Sci Rep, 8:11215-11215, 2018 Cited by PubMed: 30046154 DOI: 10.1038/s41598-018-29500-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation