4ZCS
Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase in complex with CDP-choline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| A | 0006657 | biological_process | CDP-choline pathway |
| A | 0009058 | biological_process | biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| B | 0006657 | biological_process | CDP-choline pathway |
| B | 0009058 | biological_process | biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| C | 0006657 | biological_process | CDP-choline pathway |
| C | 0009058 | biological_process | biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| D | 0006657 | biological_process | CDP-choline pathway |
| D | 0009058 | biological_process | biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| E | 0006657 | biological_process | CDP-choline pathway |
| E | 0009058 | biological_process | biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004105 | molecular_function | choline-phosphate cytidylyltransferase activity |
| F | 0006657 | biological_process | CDP-choline pathway |
| F | 0009058 | biological_process | biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue CDC A 801 |
| Chain | Residue |
| A | ASP623 |
| A | LYS663 |
| A | TRP692 |
| A | HIS709 |
| A | ASP710 |
| A | TYR714 |
| A | ILE740 |
| A | TYR741 |
| A | GLN754 |
| A | ARG755 |
| A | THR756 |
| A | GLY624 |
| A | HOH906 |
| A | HOH915 |
| A | HOH917 |
| A | HOH924 |
| A | HOH926 |
| A | HOH928 |
| A | HOH940 |
| A | VAL625 |
| A | TYR626 |
| A | HIS630 |
| A | GLY632 |
| A | HIS633 |
| A | GLN636 |
| A | THR654 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | binding site for residue CDC C 801 |
| Chain | Residue |
| C | ASP623 |
| C | GLY624 |
| C | VAL625 |
| C | TYR626 |
| C | HIS630 |
| C | GLY632 |
| C | HIS633 |
| C | GLN636 |
| C | LYS663 |
| C | TRP692 |
| C | HIS709 |
| C | ASP710 |
| C | TYR714 |
| C | ILE740 |
| C | TYR741 |
| C | GLN754 |
| C | ARG755 |
| C | THR756 |
| C | HOH906 |
| C | HOH908 |
| C | HOH910 |
| C | HOH912 |
| C | HOH914 |
| C | HOH922 |
| C | HOH926 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue CDC E 801 |
| Chain | Residue |
| E | ASP623 |
| E | GLY624 |
| E | VAL625 |
| E | TYR626 |
| E | GLY632 |
| E | HIS633 |
| E | GLN636 |
| E | LYS663 |
| E | TRP692 |
| E | HIS709 |
| E | ASP710 |
| E | TYR714 |
| E | ILE740 |
| E | TYR741 |
| E | GLN754 |
| E | ARG755 |
| E | THR756 |
| E | HOH907 |
| E | HOH910 |
| E | HOH920 |
| E | HOH929 |
| E | HOH939 |
| E | HOH941 |
| E | HOH948 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | binding site for residue CDC B 801 |
| Chain | Residue |
| B | ASP623 |
| B | GLY624 |
| B | VAL625 |
| B | TYR626 |
| B | GLY632 |
| B | HIS633 |
| B | GLN636 |
| B | THR654 |
| B | LYS663 |
| B | TRP692 |
| B | HIS709 |
| B | ASP710 |
| B | TYR714 |
| B | ILE740 |
| B | TYR741 |
| B | GLN754 |
| B | ARG755 |
| B | THR756 |
| B | HOH906 |
| B | HOH918 |
| B | HOH921 |
| B | HOH927 |
| B | HOH932 |
| B | HOH934 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue P33 B 802 |
| Chain | Residue |
| B | ASP684 |
| B | GLU685 |
| B | ILE686 |
| B | HOH911 |
| B | HOH942 |
| site_id | AC6 |
| Number of Residues | 25 |
| Details | binding site for residue CDC D 801 |
| Chain | Residue |
| D | ASP623 |
| D | GLY624 |
| D | VAL625 |
| D | TYR626 |
| D | HIS630 |
| D | GLY632 |
| D | HIS633 |
| D | GLN636 |
| D | THR654 |
| D | LYS663 |
| D | TRP692 |
| D | HIS709 |
| D | ASP710 |
| D | TYR714 |
| D | TYR741 |
| D | GLN754 |
| D | ARG755 |
| D | THR756 |
| D | HOH908 |
| D | HOH909 |
| D | HOH911 |
| D | HOH912 |
| D | HOH924 |
| D | HOH927 |
| D | HOH939 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue P33 D 802 |
| Chain | Residue |
| D | ASP684 |
| D | GLU685 |
| D | ILE686 |
| D | HOH907 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | binding site for residue CDC F 801 |
| Chain | Residue |
| F | ASP623 |
| F | GLY624 |
| F | VAL625 |
| F | TYR626 |
| F | GLY632 |
| F | HIS633 |
| F | GLN636 |
| F | THR654 |
| F | LYS663 |
| F | TRP692 |
| F | HIS709 |
| F | ASP710 |
| F | TYR714 |
| F | ILE740 |
| F | TYR741 |
| F | GLN754 |
| F | ARG755 |
| F | THR756 |
| F | HOH902 |
| F | HOH909 |
| F | HOH914 |
| F | HOH919 |
| F | HOH923 |
