4ZCS

Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase in complex with CDP-choline

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, C, E, B, D...)	Choline-phosphate cytidylyltransferase	polymer	180	20810.1	6	UniProt (Q8IEE9) Pfam (PF01467)	Plasmodium falciparum (isolate 3D7)
2	G, H, I, J, L... (A, C, E, B, D...)	[2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM	non-polymer		488.3	6	Chemie (CDC)
3	K, M (B, D)	3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL	non-polymer		326.4	2	Chemie (P33)
4	O, P, Q, R, S... (A, C, E, B, D...)	water	water		18.0	341	Chemie (HOH)

Sequence modifications

A, C, E, B, D, F: 581 - 775 (UniProt: Q8IEE9)

PDB	External Database	Details
Gly 578	-	expression tag
His 579	-	expression tag
Met 580	-	expression tag
-	Lys 720	deletion
-	Lys 721	deletion
-	Lys 722	deletion
-	Lys 723	deletion
-	Lys 724	deletion
-	Lys 725	deletion
-	Ser 726	deletion
-	Lys 727	deletion
-	Gly 728	deletion
-	Lys 729	deletion
-	Ser 730	deletion
-	Phe 731	deletion
-	Ser 732	deletion
-	Phe 733	deletion
-	Asp 734	deletion
-	Glu 735	deletion
-	Glu 736	deletion
-	Asn 737	deletion

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124860.7
Non-Polymers*	Number of molecules	8
	Total formula weight	3582.7
All*	Total formula weight	128443.4

*Water molecules are not included.