4Z55

Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of LDK378

4Z55 の概要

• エントリーDOI: 10.2210/pdb4z55/pdb
• 関連するPDBエントリー: 3L9P 3LCS 3LCT 4MKC
• 分子名称: ALK tyrosine kinase receptor, GLYCEROL, N~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidine-4,6-diamine, ... (4 entities in total)
• 機能のキーワード: catalytic domain, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : Q9UM73
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38999.80

構造登録者

Lee, C.C.,Spraggon, G. (登録日: 2015-04-02, 公開日: 2016-02-03, 最終更新日: 2024-03-06)

• 主引用文献: Michellys, P.Y.,Chen, B.,Jiang, T.,Jin, Y.,Lu, W.,Marsilje, T.H.,Pei, W.,Uno, T.,Zhu, X.,Wu, B.,Nguyen, T.N.,Bursulaya, B.,Lee, C.,Li, N.,Kim, S.,Tuntland, T.,Liu, B.,Sun, F.,Steffy, A.,Hood, T.; Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.; Bioorg.Med.Chem.Lett., 26:1090-1096, 2016; PubMed: 26750252; DOI: 10.1016/j.bmcl.2015.11.049

実験手法

X-RAY DIFFRACTION (1.55 Å)