3LCS

Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain

Summary for 3LCS

Entry DOI	10.2210/pdb3lcs/pdb
Related	3L9P 3LCT
Descriptor	ALK tyrosine kinase receptor, STAUROSPORINE, GLYCEROL, ... (4 entities in total)
Functional Keywords	kinase domain, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transmembrane, tyrosine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q9UM73
Total number of polymer chains	1
Total formula weight	39292.04
Authors	Lee, C.C. (deposition date: 2010-01-11, release date: 2010-08-04, Last modification date: 2023-09-06)
Primary citation	Lee, C.C.,Jia, Y.,Li, N.,Sun, X.,Ng, K.,Ambing, E.,Gao, M.Y.,Hua, S.,Chen, C.,Kim, S.,Michellys, P.Y.,Lesley, S.A.,Harris, J.L.,Spraggon, G. Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain. Biochem.J., 430:425-437, 2010 Cited by PubMed: 20632993 DOI: 10.1042/BJ20100609 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation