3LCS
Crystal Structure of the Anaplastic Lymphoma Kinase Catalytic Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 344 | 38641.3 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (71203703) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (42610657) PubChem (44299148) PubChem (358479) PubChem (49831000) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (12046017) PubChem (68262703) PubChem (68306294) PubChem (73953205) PubChem (86306248) PubChem (122130844) PubChem (5279) PubChem (44259) PubChem (451705) PubChem (5459111) PubChem (6419748) PubChem (9804568) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 4 | E (A) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 1072 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1067 | - | expression tag |
| Ala 1068 | - | expression tag |
| Met 1069 | - | expression tag |
| Gly 1070 | - | expression tag |
| Ser 1071 | - | expression tag |
| Gly 1281 | Ser 1281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38641.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 650.7 | |
| All* | Total formula weight | 39292.0 |
