4MKC

Crystal Structure of Anaplastic Lymphoma Kinase Complexed with LDK378

Summary for 4MKC

• Entry DOI: 10.2210/pdb4mkc/pdb
• Related: 3L9P 3LCS 3LCT
• Descriptor: ALK tyrosine kinase receptor, GLYCEROL, 5-chloro-N~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-N~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine, ... (4 entities in total)
• Functional Keywords: kinase domain, phosphotransferase, atp binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : Q9UM73
• Total number of polymer chains: 1
• Total formula weight: 42357.82

Authors

Lee, C.C.,Spraggon, G. (deposition date: 2013-09-04, release date: 2014-04-09, Last modification date: 2023-09-20)

• Primary citation: Friboulet, L.,Li, N.,Katayama, R.,Lee, C.C.,Gainor, J.F.,Crystal, A.S.,Michellys, P.Y.,Awad, M.M.,Yanagitani, N.,Kim, S.,Pferdekamper, A.C.,Li, J.,Kasibhatla, S.,Sun, F.,Sun, X.,Hua, S.,McNamara, P.,Mahmood, S.,Lockerman, E.L.,Fujita, N.,Nishio, M.,Harris, J.L.,Shaw, A.T.,Engelman, J.A.; The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non-Small Cell Lung Cancer.; Cancer Discov, 4:662-673, 2014; PubMed: 24675041; DOI: 10.1158/2159-8290.CD-13-0846

Experimental method

X-RAY DIFFRACTION (2.01 Å)