4Y6O
Human SIRT2 in complex with myristoylated peptide (TNF-alphaK20myr)
Summary for 4Y6O
Entry DOI | 10.2210/pdb4y6o/pdb |
Related | 4Y6L 4Y6Q |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, peptide LEU-PRO-LYS-MYK-THR-GLY-GLY, ZINC ION, ... (4 entities in total) |
Functional Keywords | sirtuin, sirt, nad-dependent deacetylase, myristoylated lysine, hydrolase-peptide complex, hydrolase/peptide |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 68355.67 |
Authors | Kudo, N.,Ito, A.,Yoshida, M. (deposition date: 2015-02-13, release date: 2016-01-06, Last modification date: 2023-11-08) |
Primary citation | Feldman, J.L.,Dittenhafer-Reed, K.E.,Kudo, N.,Thelen, J.N.,Ito, A.,Yoshida, M.,Denu, J.M. Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry, 54:3037-3050, 2015 Cited by PubMed: 25897714DOI: 10.1021/acs.biochem.5b00150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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