4Y6O
Human SIRT2 in complex with myristoylated peptide (TNF-alphaK20myr)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide LYS C 9 and MYK C 10 |
| Chain | Residue |
| A | PHE119 |
| A | HIS187 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | SER238 |
| A | LEU239 |
| A | GLN267 |
| A | PRO268 |
| C | LEU7 |
| C | PRO8 |
| C | THR11 |
| C | HOH101 |
| C | HOH102 |
| A | PHE96 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide MYK C 10 and THR C 11 |
| Chain | Residue |
| A | PHE96 |
| A | PHE119 |
| A | HIS187 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | LEU239 |
| A | VAL266 |
| A | GLN267 |
| C | LYS9 |
| C | GLY12 |
| C | HOH101 |
| C | HOH102 |
| C | HOH104 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide LYS D 5 and MYK D 6 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | PHE190 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | SER238 |
| B | LEU239 |
| B | GLN267 |
| B | PRO268 |
| D | LEU3 |
| D | PRO4 |
| D | THR7 |
| D | HOH101 |
| D | HOH102 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide MYK D 6 and THR D 7 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | PHE190 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | LEU239 |
| B | VAL266 |
| B | GLN267 |
| D | LYS5 |
| D | GLY8 |
| D | HOH101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | LIPID: N6-myristoyl lysine => ECO:0000269|PubMed:1402651, ECO:0000269|PubMed:23552949 |
| Chain | Residue | Details |
| C | LYS9 | |
| C | MYK10 | |
| D | LYS5 | |
| D | MYK6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25672491, ECO:0007744|PDB:4RMG |
| Chain | Residue | Details |
| A | ALA85 | |
| B | THR262 | |
| B | ASN286 | |
| B | GLY336 | |
| A | ASP95 | |
| A | GLN167 | |
| A | THR262 | |
| A | ASN286 | |
| A | GLY336 | |
| B | ALA85 | |
| B | ASP95 | |
| B | GLN167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11427894, ECO:0000269|PubMed:23454361, ECO:0000269|PubMed:24389023, ECO:0000269|PubMed:25672491, ECO:0000269|PubMed:25704306, ECO:0007744|PDB:4R8M |
| Chain | Residue | Details |
| A | CYS195 | |
| A | CYS200 | |
| A | CYS221 | |
| A | CYS224 | |
| B | CYS195 | |
| B | CYS200 | |
| B | CYS221 | |
| B | CYS224 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q5RJQ4 |
| Chain | Residue | Details |
| A | SER53 | |
| A | SER100 | |
| A | SER207 | |
| B | SER53 | |
| B | SER100 | |
| B | SER207 |
