4Y6O
Human SIRT2 in complex with myristoylated peptide (TNF-alphaK20myr)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0017136 | molecular_function | histone deacetylase activity, NAD-dependent |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS195 |
| A | CYS200 |
| A | CYS221 |
| A | CYS224 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | CYS195 |
| B | CYS200 |
| B | CYS221 |
| B | CYS224 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide LYS C 9 and MYK C 10 |
| Chain | Residue |
| A | PHE119 |
| A | HIS187 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | SER238 |
| A | LEU239 |
| A | GLN267 |
| A | PRO268 |
| C | LEU7 |
| C | PRO8 |
| C | THR11 |
| C | HOH101 |
| C | HOH102 |
| A | PHE96 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide MYK C 10 and THR C 11 |
| Chain | Residue |
| A | PHE96 |
| A | PHE119 |
| A | HIS187 |
| A | VAL233 |
| A | PHE235 |
| A | GLY236 |
| A | GLU237 |
| A | LEU239 |
| A | VAL266 |
| A | GLN267 |
| C | LYS9 |
| C | GLY12 |
| C | HOH101 |
| C | HOH102 |
| C | HOH104 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide LYS D 5 and MYK D 6 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | PHE190 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | SER238 |
| B | LEU239 |
| B | GLN267 |
| B | PRO268 |
| D | LEU3 |
| D | PRO4 |
| D | THR7 |
| D | HOH101 |
| D | HOH102 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide MYK D 6 and THR D 7 |
| Chain | Residue |
| B | PHE96 |
| B | PHE143 |
| B | HIS187 |
| B | PHE190 |
| B | VAL233 |
| B | PHE235 |
| B | GLY236 |
| B | GLU237 |
| B | LEU239 |
| B | VAL266 |
| B | GLN267 |
| D | LYS5 |
| D | GLY8 |
| D | HOH101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"N6-myristoyl lysine","evidences":[{"source":"PubMed","id":"1402651","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
