4WXG

Crystal structure of L-Serine Hydroxymethyltransferase in complex with a mixture of L-Threonine and Glycine

Summary for 4WXG

Entry DOI	10.2210/pdb4wxg/pdb
Descriptor	Serine hydroxymethyltransferase, N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-threonine, SODIUM ION, ... (5 entities in total)
Functional Keywords	aldolase, transferase, aldehydes, catalysis, catalytic domain, dimerization, glycine hydroxymethyltransferase, l-allo-threonine, protein binding, threonine aldolase
Biological source	Streptococcus thermophilus
Total number of polymer chains	2
Total formula weight	93925.68
Authors	Hernandez, K.,Zelen, I.,Petrillo, G.,Uson, I.,Wandtke, C.,Bujons, J.,Joglar, J.,Parella, T.,Clapes, P. (deposition date: 2014-11-13, release date: 2015-02-04, Last modification date: 2024-01-10)
Primary citation	Hernandez, K.,Zelen, I.,Petrillo, G.,Uson, I.,Wandtke, C.M.,Bujons, J.,Joglar, J.,Parella, T.,Clapes, P. Engineered L-Serine Hydroxymethyltransferase from Streptococcus thermophilus for the Synthesis of alpha , alpha-Dialkyl-alpha-Amino Acids. Angew.Chem.Int.Ed.Engl., 54:3013-3017, 2015 Cited by PubMed: 25611820 DOI: 10.1002/anie.201411484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation