4WXG

Crystal structure of L-Serine Hydroxymethyltransferase in complex with a mixture of L-Threonine and Glycine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006544	biological_process	glycine metabolic process
A	0006545	biological_process	glycine biosynthetic process
A	0006563	biological_process	L-serine metabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0046653	biological_process	tetrahydrofolate metabolic process
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006544	biological_process	glycine metabolic process
C	0006545	biological_process	glycine biosynthetic process
C	0006563	biological_process	L-serine metabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019264	biological_process	glycine biosynthetic process from serine
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0046653	biological_process	tetrahydrofolate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue 2BO A 501

Chain	Residue
A	SER35
A	THR227
A	HIS229
A	LYS230
A	ARG363
A	HOH636
A	HOH681
C	TYR55
C	GLU57
C	TYR65
C	GLY261
A	SER97
C	GLY262
C	HOH602
A	GLY98
A	SER99
A	HIS126
A	SER176
A	ASP201
A	ALA203
A	HIS204

---

site_id	AC2
Number of Residues	4
Details	binding site for residue NA A 502

Chain	Residue
A	PHE301
A	ASN302
A	HIS304
A	PHE307

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 503

Chain	Residue
A	LEU154
A	TYR156
A	ARG180
A	ASP183
A	HOH664
A	HOH664
A	HOH683
A	HOH711
A	HOH752

---

site_id	AC4
Number of Residues	21
Details	binding site for residue 2BO C 501

Chain	Residue
A	TYR55
A	GLU57
A	TYR65
A	GLY261
A	GLY262
A	HOH601
C	SER35
C	SER97
C	GLY98
C	SER99
C	HIS126
C	SER176
C	ASP201
C	ALA203
C	HIS204
C	THR227
C	HIS229
C	LYS230
C	ARG363
C	HOH675
C	HOH713

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NA C 502

Chain	Residue
C	PHE301
C	ASN302
C	HIS304
C	PHE307

---

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVtTTTTHKTLrGPRGG

Chain	Residue	Details
A	HIS222-GLY238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Plays an important role in substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00051","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---