4WX2

Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with two F6F molecules in the alpha-site and one F6F molecule in the beta-site

Summary for 4WX2

Entry DOI	10.2210/pdb4wx2/pdb
Related	2CLE 2CLF 2CLM 4KKX
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (8 entities in total)
Functional Keywords	carbon-oxygen lyase, tryptophan biosynthesis, salmonella typhimurium, f6f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, transferase
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Total number of polymer chains	2
Total formula weight	73043.49
Authors	Hilario, E.,Caulkins, B.G.,Young, R.P.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2014-11-13, release date: 2015-11-18, Last modification date: 2023-09-27)
Primary citation	Hilario, E.,Caulkins, B.G.,Huang, Y.M.,You, W.,Chang, C.E.,Mueller, L.J.,Dunn, M.F.,Fan, L. Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water. Biochim.Biophys.Acta, 1864:268-279, 2016 Cited by PubMed: 26708480 DOI: 10.1016/j.bbapap.2015.12.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation