4KKX

Crystal structure of Tryptophan Synthase from Salmonella typhimurium with 2-aminophenol quinonoid in the beta site and the F6 inhibitor in the alpha site

Summary for 4KKX

Entry DOI	10.2210/pdb4kkx/pdb
Related	2CLE 2CLF 2CLM 3CEP 3PR2 4HPJ
Descriptor	Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (9 entities in total)
Functional Keywords	lyase, carbon-oxygen lyase, tryptophan biosynthesis, f6f, allosteric enzyme, 2-aminophenol quinonoid, biosynthesis, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Salmonella enterica subsp. enterica serovar Typhimurium More
Total number of polymer chains	2
Total formula weight	73576.42
Authors	Hilario, E.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2013-05-06, release date: 2014-01-01, Last modification date: 2023-09-20)
Primary citation	Niks, D.,Hilario, E.,Dierkers, A.,Ngo, H.,Borchardt, D.,Neubauer, T.J.,Fan, L.,Mueller, L.J.,Dunn, M.F. Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry, 52:6396-6411, 2013 Cited by PubMed: 23952479 DOI: 10.1021/bi400795e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation