2CLM

Tryptophan Synthase (external aldimine state) in complex with N-(4'- trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F)

Summary for 2CLM

Entry DOI	10.2210/pdb2clm/pdb
Related	1A50 1A5A 1A5B 1A5S 1BEU 1BKS 1C29 1C8V 1C9D 1CW2 1CX9 1FUY 1K3U 1K7E 1K7F 1K7X 1K8X 1K8Y 1K8Z 1KFB 1KFC 1KFE 1KFJ 1KFK 1QOP 1QOQ 1TJP 1TTP 1TTQ 1UBS 1WBJ 2CLE 2CLF 2CLI 2CLK 2CLL 2CLO 2TRS 2TSY 2TYS 2WSY
Descriptor	TRYPTOPHAN SYNTHASE ALPHA CHAIN, TRYPTOPHAN SYNTHASE BETA CHAIN, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
Functional Keywords	aromatic amino acid biosynthesis, carbon-oxygen lyase, amino-acid biosynthesis, tryptophan biosynthesis, lyase, allosteric enzyme, pyridoxal phosphate
Biological source	SALMONELLA TYPHIMURIUM More
Total number of polymer chains	2
Total formula weight	72244.99
Authors	Ngo, H.,Kimmich, N.,Harris, R.,Niks, D.,Blumenstein, L.,Kulik, V.,Barends, T.R.,Schlichting, I.,Dunn, M.F. (deposition date: 2006-04-28, release date: 2007-06-12, Last modification date: 2011-07-13)
Primary citation	Ngo, H.,Kimmich, N.,Harris, R.,Niks, D.,Blumenstein, L.,Kulik, V.,Barends, T.R.,Schlichting, I.,Dunn, M.F. Allosteric Regulation of Substrate Channeling in Tryptophan Synthase: Modulation of the L-Serine Reaction in Stage I of the Beta-Reaction by Alpha-Site Ligands. Biochemistry, 46:7740-, 2007 Cited by PubMed: 17559232 DOI: 10.1021/BI7003872 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation