Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 1.5 Angstrom resolution

Summary for 4WND

Related3SF4 4WNE 4WNF 4WNG
DescriptorG-protein-signaling modulator 2, FERM and PDZ domain-containing protein 4, THIOCYANATE ION, ... (7 entities in total)
Functional Keywordstetratricopeptide repeat, tpr, cell polarity, cytoplasm and cell cortex, signaling protein-protein binding complex, signaling protein/protein binding
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P81274
Cell projection, dendritic spine  Q14CM0
Total number of polymer chains2
Total molecular weight52239.66
Takayanagi, H.,Yuzawa, S.,Sumimoto, H. (deposition date: 2014-10-11, release date: 2015-09-16)
Primary citation
Takayanagi, H.,Yuzawa, S.,Sumimoto, H.
Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN
Acta Crystallogr.,Sect.F, 71:175-183, 2015
PubMed: 25664792 (PDB entries with the same primary citation)
DOI: 10.1107/S2053230X14028143
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19350.3%0.7%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution