4WND

Crystal structure of the TPR domain of LGN in complex with Frmpd4/Preso1 at 1.5 Angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	G-protein-signaling modulator 2	polymer	406	44948.3	1	UniProt (P81274) Pfam (PF13374) Pfam (PF13176) Pfam (PF13181) In PDB	Homo sapiens (Human)	Mosaic protein LGN
2	B	FERM and PDZ domain-containing protein 4	polymer	53	5831.6	1	UniProt (Q14CM0) In PDB	Homo sapiens (Human)	PDZ domain-containing protein 10,PSD-95-interacting regulator of spine morphogenesis,Preso
3	A	THIOCYANATE ION	non-polymer		58.1	7	Chemie (SCN)
4	A	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	5	Chemie (PEG)
5	A	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
6	A	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
7		water	water		18.0	298	Chemie (HOH)

Sequence modifications

A: 13 - 414 (UniProt: P81274)

PDB	External Database	Details
Gly 9	-	expression tag
Pro 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag

B: 978 - 1025 (UniProt: Q14CM0)

PDB	External Database	Details
Gly 973	-	expression tag
Pro 974	-	expression tag
Leu 975	-	expression tag
Gly 976	-	expression tag
Ser 977	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50779.9
Non-Polymers*	Number of molecules	19
	Total formula weight	1459.8
All*	Total formula weight	52239.7

*Water molecules are not included.