4WI1
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506
Summary for 4WI1
Entry DOI | 10.2210/pdb4wi1/pdb |
Related | 4NCX 4OLF 4Q15 |
Descriptor | Proline--tRNA ligase, 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea, 1,2-ETHANEDIOL, ... (7 entities in total) |
Functional Keywords | ssgcid, plasmodium falciparum, prolyl-trna synthetase, prors, proline--trna ligase, structural genomics, seattle structural genomics center for infectious disease, ligase |
Biological source | Plasmodium falciparum |
Cellular location | Cytoplasm : Q8I5R7 |
Total number of polymer chains | 2 |
Total formula weight | 119832.50 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2014-09-25, release date: 2016-05-04, Last modification date: 2023-09-27) |
Primary citation | Nakazawa Hewitt, S.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.S.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C. Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase. Acs Infect Dis., 2016 Cited by PubMed: 27798837DOI: 10.1021/acsinfecdis.6b00078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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