4WI1
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proline--tRNA ligase | polymer | 506 | 58986.5 | 2 | UniProt (Q8I5R7) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Plasmodium falciparum | Prolyl-tRNA synthetase,ProRS |
| 2 | C, N (A, B) | 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | non-polymer | 396.3 | 2 | Chemie (3O6) | |||
| 3 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 4 | K (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | L, V (A, B) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 6 | M (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | W, X (A, B) | water | water | 18.0 | 765 | Chemie (HOH) |
Sequence modifications
A, B: 249 - 746 (UniProt: Q8I5R7)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | expression tag |
| Ala 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 117973.0 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1859.5 | |
| All* | Total formula weight | 119832.5 |
