4NCX

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum 3D7

Summary for 4NCX

• Entry DOI: 10.2210/pdb4ncx/pdb
• Descriptor: Proline--tRNA ligase, 1,2-ETHANEDIOL, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, ligase, prolyl-trna synthetase
• Biological source: Plasmodium falciparum 3D7
• Cellular location: Cytoplasm : Q8I5R7
• Total number of polymer chains: 2
• Total formula weight: 118451.76

Authors

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2013-10-25, release date: 2014-10-29, Last modification date: 2023-09-20)

• Primary citation: Hewitt, S.N.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C.; Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.; Acs Infect Dis., 3:34-44, 2017; PubMed: 27798837; DOI: 10.1021/acsinfecdis.6b00078

Experimental method

X-RAY DIFFRACTION (1.85 Å)