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4NCX

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum 3D7

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004827molecular_functionproline-tRNA ligase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006418biological_processtRNA aminoacylation for protein translation
A0006433biological_processprolyl-tRNA aminoacylation
B0000166molecular_functionnucleotide binding
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004827molecular_functionproline-tRNA ligase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0006418biological_processtRNA aminoacylation for protein translation
B0006433biological_processprolyl-tRNA aminoacylation
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 801
ChainResidue
AALA290
ASER536
ALYS537
ATYR538
AILE595
AHOH938
AHOH1029

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EDO A 802
ChainResidue
ALYS422
AHOH962
AHOH990
AHOH1015
AHOH1133
AHOH1207
ALEU309
ALYS381

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 803
ChainResidue
AGLN475
ATHR478
AGLY510
AARG514
AHOH934

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE EDO A 804
ChainResidue
AGLU312
AHOH915
AHOH1063
BPRO289
BALA290
BTYR293
BLYS537
BEDO801
BHOH1134

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 805
ChainResidue
ATHR321
BPHE393

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 806
ChainResidue
APRO533
AHOH1034
AHOH1056
AHOH1098

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO B 801
ChainResidue
AEDO804
AHOH967
BSER536
BLYS537
BTYR538
BILE595
BHOH1134

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO B 802
ChainResidue
BASP525
BLYS527
BASP617
BASN619
BGLU688

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|Ref.7, ECO:0007744|PDB:6T7K
ChainResidueDetails
AARG390
AHIS480
BARG390
BHIS480

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:25817387, ECO:0000269|PubMed:27798837, ECO:0000269|Ref.4, ECO:0007744|PDB:4OLF, ECO:0007744|PDB:4Q15, ECO:0007744|PDB:4YDQ
ChainResidueDetails
AARG401
AGLN475
ATHR512
BARG401
BGLN475
BTHR512

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PDB entries from 2024-11-06

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