4WI1

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum in complex with TCMDC-124506

Summary for 4WI1

• Entry DOI: 10.2210/pdb4wi1/pdb
• Related: 4NCX 4OLF 4Q15
• Descriptor: Proline--tRNA ligase, 1-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea, 1,2-ETHANEDIOL, ... (7 entities in total)
• Functional Keywords: ssgcid, plasmodium falciparum, prolyl-trna synthetase, prors, proline--trna ligase, structural genomics, seattle structural genomics center for infectious disease, ligase
• Biological source: Plasmodium falciparum
• Cellular location: Cytoplasm : Q8I5R7
• Total number of polymer chains: 2
• Total formula weight: 119832.50

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2014-09-25, release date: 2016-05-04, Last modification date: 2023-09-27)

• Primary citation: Nakazawa Hewitt, S.,Dranow, D.M.,Horst, B.G.,Abendroth, J.A.,Forte, B.,Hallyburton, I.,Jansen, C.,Baragana, B.,Choi, R.,Rivas, K.L.,Hulverson, M.A.,Dumais, M.,Edwards, T.E.,Lorimer, D.D.,Fairlamb, A.H.,Gray, D.W.,Read, K.D.,Lehane, A.M.,Kirk, K.,Myler, P.J.,Wernimont, A.,Walpole, C.S.,Stacy, R.,Barrett, L.K.,Gilbert, I.H.,Van Voorhis, W.C.; Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.; Acs Infect Dis., 2016; PubMed: 27798837; DOI: 10.1021/acsinfecdis.6b00078

Experimental method

X-RAY DIFFRACTION (1.65 Å)