4UXQ
FGFR4 in complex with Ponatinib
Summary for 4UXQ
Entry DOI | 10.2210/pdb4uxq/pdb |
Related | 4V01 4V04 4V05 |
Descriptor | FIBROBLAST GROWTH FACTOR RECEPTOR 4, SULFATE ION, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, ... (4 entities in total) |
Functional Keywords | transferase, kinase dfg-out fgfr inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455 |
Total number of polymer chains | 1 |
Total formula weight | 35083.35 |
Authors | Tucker, J.,Klein, T.,Breed, J.,Breeze, A.,Overman, R.,Phillips, C.,Norman, R.A. (deposition date: 2014-08-27, release date: 2014-12-03, Last modification date: 2024-05-08) |
Primary citation | Tucker, J.A.,Klein, T.,Breed, J.,Breeze, A.L.,Overman, R.,Phillips, C.,Norman, R.A. Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4 Structure, 22:1764-, 2014 Cited by PubMed: 25465127DOI: 10.1016/J.STR.2014.09.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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