4UDC

GR in complex with dexamethasone

Summary for 4UDC

Related4UDA 4UDB 4UDD
DescriptorGLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (5 entities in total)
Functional Keywordssignaling protein, nuclear hormone receptor, ligand complex, peptide complex
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm . Isoform Beta: Nucleus P04150
Nucleus Q15596
Total number of polymer chains2
Total molecular weight34871.34
Authors
Primary citation
Edman, K.,Hosseini, A.,Bjursell, M.K.,Aagaard, A.,Wissler, L.,Gunnarsson, A.,Kaminski, T.,Kohler, C.,Backstrom, S.,Jensen, T.J.,Cavallin, A.,Karlsson, U.,Nilsson, E.,Lecina, D.,Takahashi, R.,Grebner, C.,Geschwindner, S.,Lepisto, M.,Hogner, A.C.,Guallar, V.
Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints.
Structure, 23:2280-, 2015
PubMed: 26602186 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2015.09.012
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23710.4%2.5%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 4udc
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Molmil generated image of 4udc
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