4UDC
GR in complex with dexamethasone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUCOCORTICOID RECEPTOR | polymer | 280 | 32155.1 | 1 | UniProt (P04150) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | GR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1 |
| 2 | B (B) | NUCLEAR RECEPTOR COACTIVATOR 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) | HOMO SAPIENS | NCOA-2, CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 75, BHLHE75, TRANSCRIPTIONAL INTERMEDIARY FACTOR 2, HTIF2, NCOA2 |
| 3 | C (A) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 1 | Chemie (CPS) | |||
| 4 | D (A) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Asp 517 | Asn 517 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33864.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1007.3 | |
| All* | Total formula weight | 34871.3 |
