4S1T

Crystal structure of the mutant I26A/N52A of the endoribonuclease from human coronavirus 229E

Summary for 4S1T

• Entry DOI: 10.2210/pdb4s1t/pdb
• Descriptor: Uridylate-specific endoribonuclease, PHOSPHATE ION (3 entities in total)
• Functional Keywords: hcov-229e, endoribonuclease, trimeric nsp15, double mutation, hydrolase
• Biological source: Human coronavirus 229E (HCoV-229E)
• Cellular location: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X1
• Total number of polymer chains: 6
• Total formula weight: 233503.23

Authors

Huo, T.,Liu, X. (deposition date: 2015-01-15, release date: 2016-01-20, Last modification date: 2023-11-08)

• Primary citation: Huo, T.,Liu, X.,Yang, C.,Rao, Z.; Crystal structure and mutational analysis of the endoribonuclease from human coronavirus 229E; To be Published,

Experimental method

X-RAY DIFFRACTION (2.504 Å)