4S10

Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis

Summary for 4S10

• Entry DOI: 10.2210/pdb4s10/pdb
• Related: 4S11
• Descriptor: GELSOLIN NANOBODY, Gelsolin, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: gelsolin-like, actin-binding, metal binding protein-immune system complex, metal binding protein/immune system
• Biological source: Lama glama; More
• Cellular location: Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396
• Total number of polymer chains: 4
• Total formula weight: 50431.58

Authors

Wongsantichon, J.,Robinson, R.C.,Gettemans, J. (deposition date: 2015-01-07, release date: 2015-06-03)

• Primary citation: Van Overbeke, W.,Wongsantichon, J.,Everaert, I.,Verhelle, A.,Zwaenepoel, O.,Loonchanta, A.,Burtnick, L.D.,De Ganck, A.,Hochepied, T.,Haigh, J.,Cuvelier, C.,Derave, W.,Robinson, R.C.,Gettemans, J.; An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model.; Hum.Mol.Genet., 24:2492-2507, 2015; PubMed: 25601851; DOI: 10.1093/hmg/ddv010

Experimental method

X-RAY DIFFRACTION (2.614 Å)