4S10
Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
Summary for 4S10
Entry DOI | 10.2210/pdb4s10/pdb |
Related | 4S11 |
Descriptor | GELSOLIN NANOBODY, Gelsolin, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | gelsolin-like, actin-binding, metal binding protein-immune system complex, metal binding protein/immune system |
Biological source | Lama glama More |
Cellular location | Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396 |
Total number of polymer chains | 4 |
Total formula weight | 50431.58 |
Authors | Wongsantichon, J.,Robinson, R.C.,Gettemans, J. (deposition date: 2015-01-07, release date: 2015-06-03) |
Primary citation | Van Overbeke, W.,Wongsantichon, J.,Everaert, I.,Verhelle, A.,Zwaenepoel, O.,Loonchanta, A.,Burtnick, L.D.,De Ganck, A.,Hochepied, T.,Haigh, J.,Cuvelier, C.,Derave, W.,Robinson, R.C.,Gettemans, J. An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model. Hum.Mol.Genet., 24:2492-2507, 2015 Cited by PubMed: 25601851DOI: 10.1093/hmg/ddv010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.614 Å) |
Structure validation
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