4S10
Gelsolin nanobody shielding mutant plasma gelsolin from furin proteolysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | GELSOLIN NANOBODY | polymer | 127 | 13696.0 | 2 | Lama glama | ||
| 2 | B, D (C, D) | Gelsolin | polymer | 103 | 11479.7 | 2 | UniProt (P06396) Pfam (PF00626) | Homo sapiens (human) | AGEL, Actin-depolymerizing factor, ADF, Brevin |
| 3 | E, F (C, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | G, H, I, J (A, C, B, D) | water | water | 18.0 | 104 | Chemie (HOH) |
Sequence modifications
C, D: 159 - 261 (UniProt: P06396)
| PDB | External Database | Details |
|---|---|---|
| Asp 226 | Ser 253 | ENGINEERED MUTATION |
| Asp 228 | Arg 255 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 50351.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 80.2 | |
| All* | Total formula weight | 50431.6 |
