4RYD
X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Summary for 4RYD
Entry DOI | 10.2210/pdb4ryd/pdb |
Related | 1P8J 4OMC 4OMD |
Related PRD ID | PRD_001257 |
Descriptor | Furin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total) |
Functional Keywords | competitive inhibitor, pro-protein convertase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958 |
Total number of polymer chains | 12 |
Total formula weight | 320519.12 |
Authors | Dahms, S.O.,Than, M.E. (deposition date: 2014-12-15, release date: 2015-05-27, Last modification date: 2024-07-10) |
Primary citation | Hardes, K.,Becker, G.L.,Lu, Y.,Dahms, S.O.,Kohler, S.,Beyer, W.,Sandvig, K.,Yamamoto, H.,Lindberg, I.,Walz, L.,von Messling, V.,Than, M.E.,Garten, W.,Steinmetzer, T. Novel Furin Inhibitors with Potent Anti-infectious Activity. Chemmedchem, 10:1218-1231, 2015 Cited by PubMed: 25974265DOI: 10.1002/cmdc.201500103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report