4RYD

X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba

4RYD の概要

• エントリーDOI: 10.2210/pdb4ryd/pdb
• 関連するPDBエントリー: 1P8J 4OMC 4OMD
• 関連するBIRD辞書のPRD_ID: PRD_001257
• 分子名称: Furin, para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine, FORMIC ACID, ... (6 entities in total)
• 機能のキーワード: competitive inhibitor, pro-protein convertase, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P09958
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 320519.12

構造登録者

Dahms, S.O.,Than, M.E. (登録日: 2014-12-15, 公開日: 2015-05-27, 最終更新日: 2015-07-15)

• 主引用文献: Hardes, K.,Becker, G.L.,Lu, Y.,Dahms, S.O.,Kohler, S.,Beyer, W.,Sandvig, K.,Yamamoto, H.,Lindberg, I.,Walz, L.,von Messling, V.,Than, M.E.,Garten, W.,Steinmetzer, T.; Novel Furin Inhibitors with Potent Anti-infectious Activity.; Chemmedchem, 10:1218-1231, 2015; PubMed: 25974265; DOI: 10.1002/cmdc.201500103

実験手法

X-RAY DIFFRACTION (2.15 Å)