4RHU

Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

Summary for 4RHU

• Entry DOI: 10.2210/pdb4rhu/pdb
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase Hpt, {[(2R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)propane-1,2-diyl]bis(oxyethane-2,1-diyl)}bis(phosphonic acid), MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 6-oxopurine phosphoribosyltransferase, purine salvage pathway, hypoxanthine-guanine phosphoribosyltransferase, acyclic nucleoside phosphonate inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 6
• Total formula weight: 135687.57

Authors

Eng, W.S.,Hockova, D.,Spacek, P.,West, N.P.,Woods, K.,Naesens, L.M.J.,Keough, D.T.,Guddat, L.W. (deposition date: 2014-10-03, release date: 2015-05-20, Last modification date: 2023-09-20)

• Primary citation: Eng, W.S.,Hockova, D.,Spacek, P.,Janeba, Z.,West, N.P.,Woods, K.,Naesens, L.M.,Keough, D.T.,Guddat, L.W.; First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.; J.Med.Chem., 58:4822-4838, 2015; PubMed: 25915781; DOI: 10.1021/acs.jmedchem.5b00611

Experimental method

X-RAY DIFFRACTION (2.573 Å)