4RHU
Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006178 | biological_process | guanine salvage |
| C | 0006188 | biological_process | IMP biosynthetic process |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0043101 | biological_process | purine-containing compound salvage |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006178 | biological_process | guanine salvage |
| D | 0006188 | biological_process | IMP biosynthetic process |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0043101 | biological_process | purine-containing compound salvage |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006166 | biological_process | purine ribonucleoside salvage |
| E | 0006177 | biological_process | GMP biosynthetic process |
| E | 0006178 | biological_process | guanine salvage |
| E | 0006188 | biological_process | IMP biosynthetic process |
| E | 0032263 | biological_process | GMP salvage |
| E | 0032264 | biological_process | IMP salvage |
| E | 0043101 | biological_process | purine-containing compound salvage |
| E | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006166 | biological_process | purine ribonucleoside salvage |
| F | 0006177 | biological_process | GMP biosynthetic process |
| F | 0006178 | biological_process | guanine salvage |
| F | 0006188 | biological_process | IMP biosynthetic process |
| F | 0032263 | biological_process | GMP salvage |
| F | 0032264 | biological_process | IMP salvage |
| F | 0043101 | biological_process | purine-containing compound salvage |
| F | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 3QE A 301 |
| Chain | Residue |
| A | LEU65 |
| A | ASP174 |
| A | PHE175 |
| A | VAL176 |
| A | LEU181 |
| A | ASP182 |
| A | ARG188 |
| A | HOH415 |
| A | LYS66 |
| A | VAL124 |
| A | ASP126 |
| A | SER127 |
| A | GLY128 |
| A | LEU129 |
| A | THR130 |
| A | LYS154 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | GLU122 |
| A | ASP123 |
| A | HOH415 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 3QE B 301 |
| Chain | Residue |
| B | LYS66 |
| B | GLY67 |
| B | VAL124 |
| B | VAL125 |
| B | ASP126 |
| B | SER127 |
| B | GLY128 |
| B | THR130 |
| B | LYS154 |
| B | ASP174 |
| B | PHE175 |
| B | VAL176 |
| B | LEU181 |
| B | ASP182 |
| B | ARG188 |
| B | MG303 |
| B | HOH401 |
| B | HOH416 |
| F | GLN202 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 302 |
| Chain | Residue |
| B | GLU122 |
| B | ASP123 |
| B | HOH402 |
| B | HOH415 |
| B | HOH416 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 303 |
| Chain | Residue |
| B | ASP182 |
| B | 3QE301 |
| B | HOH414 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 45T C 301 |
| Chain | Residue |
| C | ASP123 |
| C | VAL124 |
| C | ASP126 |
| C | SER127 |
| C | GLY128 |
| C | THR130 |
| C | LYS154 |
| C | ASP174 |
| C | PHE175 |
| C | VAL176 |
| C | LEU181 |
| C | ASP182 |
| C | ARG188 |
| C | HOH404 |
| C | HOH412 |
| C | HOH420 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 302 |
| Chain | Residue |
| C | GLU122 |
| C | ASP123 |
| C | HOH412 |
| C | HOH413 |
| C | HOH414 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 45T D 301 |
| Chain | Residue |
| D | LYS66 |
| D | VAL124 |
| D | ASP126 |
| D | SER127 |
| D | GLY128 |
| D | LEU129 |
| D | THR130 |
| D | LYS154 |
| D | VAL176 |
| D | LEU181 |
| D | ASP182 |
| D | ARG188 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 302 |
| Chain | Residue |
| D | GLU122 |
| D | ASP123 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 45T E 301 |
| Chain | Residue |
| E | VAL124 |
| E | ASP126 |
| E | SER127 |
| E | GLY128 |
| E | LEU129 |
| E | THR130 |
| E | LYS154 |
| E | PHE175 |
| E | VAL176 |
| E | ASP182 |
| E | ARG188 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG E 302 |
| Chain | Residue |
| E | GLU122 |
| E | ASP123 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 45T F 301 |
| Chain | Residue |
| F | ASP126 |
| F | SER127 |
| F | GLY128 |
| F | LEU129 |
| F | THR130 |
| F | LYS154 |
| F | ASP174 |
| F | PHE175 |
| F | VAL176 |
| F | LEU181 |
| F | ASP182 |
| F | ARG188 |
| F | MG302 |
| F | HOH402 |
| F | HOH405 |
| F | HOH411 |
| F | HOH413 |
| B | GLN202 |
| F | LEU65 |
| F | LYS66 |
| F | GLY67 |
| F | VAL124 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG F 302 |
| Chain | Residue |
| F | ASP182 |
| F | ARG188 |
| F | 45T301 |
| F | HOH405 |
| F | HOH411 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG F 303 |
| Chain | Residue |
| F | GLU122 |
| F | ASP123 |
| F | HOH413 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDVVDSGlT |
| Chain | Residue | Details |
| A | VAL118-THR130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P0A9M2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25915781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RHT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KNP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25915781","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RHT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
