4QOK

Structural basis for ineffective T-cell responses to MHC anchor residue improved heteroclitic peptides

Summary for 4QOK

• Entry DOI: 10.2210/pdb4qok/pdb
• Related: 3HG1 4JFD
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1 marker peptide, ... (7 entities in total)
• Functional Keywords: immunoglobulin, hla, tcr, melanoma, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769; Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
• Total number of polymer chains: 5
• Total formula weight: 93657.81

Authors

Rizkallah, P.J.,Cole, D.K.,Madura, F.,Sewell, A.K. (deposition date: 2014-06-20, release date: 2014-12-17, Last modification date: 2023-09-20)

• Primary citation: Madura, F.,Rizkallah, P.J.,Holland, C.J.,Fuller, A.,Bulek, A.,Godkin, A.J.,Schauenburg, A.J.,Cole, D.K.,Sewell, A.K.; Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides.; Eur.J.Immunol., 45:584-591, 2015; PubMed: 25471691; DOI: 10.1002/eji.201445114

Experimental method

X-RAY DIFFRACTION (3 Å)