4QJZ
Pneumocystis carinii dihydrofolate reductase ternary complex with NADPH and the inhibitor 24, (N~6~-METHYL-N~6~-(NAPHTHALEN-1-YL)PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)
Summary for 4QJZ
Entry DOI | 10.2210/pdb4qjz/pdb |
Related | 4IXE 4QJC |
Descriptor | Dihydrofolate reductase, N~6~-methyl-N~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | rossman fold, hydrolase, nadph and folate inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Pneumocystis carinii |
Total number of polymer chains | 1 |
Total formula weight | 24980.32 |
Authors | Cody, V. (deposition date: 2014-06-05, release date: 2015-06-10, Last modification date: 2023-09-20) |
Primary citation | Cody, V.,Pace, J.,Namjoshi, O.A.,Gangjee, A. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71:799-803, 2015 Cited by PubMed: 26057816DOI: 10.1107/S2053230X15008468 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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